Perspectives

Trypanosome RNA Editin--Resolved

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Science  30 Aug 1996:
Vol. 273, Issue 5279, pp. 1182-1183
DOI: 10.1126/science.273.5279.1182

Summary

In trypanosomes, mitochondrial RNAs are modified after their synthesis. Uridylate residues are inserted into the RNA transcript or, less often, deleted. In a research article in this week's issue, Kable et al. (p. 1189) describe the mechanism whereby uridylate residues are inserted into these RNAs. Sollner-Webb discusses the discoveries and ideas that led to this breakthrough and the questions remaining for the field.