Out, Damned CLIP! Out, I Say!

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Science  25 Oct 1996:
Vol. 274, Issue 5287, pp. 526-527
DOI: 10.1126/science.274.5287.526


The major histocompatibility complex (MHC) class II molecule displays peptide fragments of foreign proteins to trigger a defensive reaction from the immune system. Before insertion of the foreign peptides into the class II binding groove, a place-holding peptide CLIP must be removed. This is accomplished by the molecule DM, which is shown to increase the dissociation rate of a small class II-associated Ii peptide (CLIP) from class II (see report by Weber et al., p. 618). Roche explains how DM can tell the difference between the class II-CLIP and foreign peptide-CLIP complexes.