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Filling In the Blanks in the p53 Protein Structure

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Science  08 Nov 1996:
Vol. 274, Issue 5289, pp. 921-922
DOI: 10.1126/science.274.5289.921


Because the p53 protein plays a critical role in protecting cells against cancer, researchers want to understand all aspects of its structure and function. In work reported in this issue (p.948) , researchers have now solved the three-dimensional structure of one previously unvisualized section of the protein—a key regulatory region in association with its regulator, a protein called MDM2. In an accompanying paper (p.1001), they also take a look at p53's interaction with another protein that may be involved in controlling the tumor suppressor's activity.