Lipid A--Target for Antibacterial Drugs

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Science  08 Nov 1996:
Vol. 274, Issue 5289, pp. 939
DOI: 10.1126/science.274.5289.939


Bacteria are rapidly developing resistance to drugs, rendering treatment of some diseases difficult or impossible. A report by Onishi et al. in this issue (p. 980) announces the discovery of a new drug directed at a never-before-assaulted part of the bacteria, the lipid A portion of the bacterial outer membrane. In his Perspective, Vaara discusses the worldwide problem of drug-resistant pathogenic bacteria and how this new agent exemplifies the tack we must now take to fight these diseases.