Developmental Neurobiology: Guiding Neurons to the Cortex

Science  15 Nov 1996:
Vol. 274, Issue 5290, pp. 1100-1101
DOI: 10.1126/science.274.5290.1100

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Both humans and mice are affected by mutations that apparently interfere with the migration of cortical neurons from their birthplace deep in the brain to their final destinations in the cortex. Recently, neuroscientists have begun cloning the genes at fault, and this should help them piece together the signaling pathways the neurons use in finding their way.