Articles

Patterning the Vertebrate Neuraxis

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Science  15 Nov 1996:
Vol. 274, Issue 5290, pp. 1109-1115
DOI: 10.1126/science.274.5290.1109

Abstract

Neuraxial patterning is a continuous process that extends over a protracted period of development. During gastrulation a crude anteroposterior pattern, detectable by molecular markers, is conferred on the neuroectoderm by signals from the endomesoderm that are largely inseparable from those of neural induction itself. This coarse-grained pattern is subsequently reinforced and refined by diverse, locally acting mechanisms. Segmentation and long-range signaling from organizing centers are prominent among the emerging principles governing regional pattern.