Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23

Science  15 Nov 1996:
Vol. 274, Issue 5290, pp. 1197-1199
DOI: 10.1126/science.274.5290.1197


Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1 percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in a large kindred with autosomal dominant PD, with a Zmax = 6.00 for marker D4S2380. This finding will facilitate identification of the gene and research on the pathogenesis of PD.

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