Perspectives

Hats Off to the Tricorn Protease

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Science  22 Nov 1996:
Vol. 274, Issue 5291, pp. 1323-1324
DOI: 10.1126/science.274.5291.1323

Summary

Cells regulate the destruction of proteins, just as they carefully regulate protein synthesis. Much of the proteolysis of cellular proteins occurs within a cylindrical organelle, the proteasome. Now Tamura et al. (p. 1385 of this issue) report the existence of a second new proteolytic organelle, the tricorn protease, in the bacteria Thermoplasma acidophilum. In their Perspective, Schneider and Hartl compare the structure and function of the proteasome and the tricorn protease.