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HIV's Other Immune-System Targets: Macrophages

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Science  29 Nov 1996:
Vol. 274, Issue 5292, pp. 1464-1465
DOI: 10.1126/science.274.5292.1464


Varenna, Italy—Last month, more than 100 AIDS experts gathered here to contemplate a major unsolved riddle of HIV infection: What role do immune-system cells other than T lymphocytes play in the progression of the disease? Researchers reported that macrophages and dendritic cells may be an important site of virus production and may also be HIV's gateway to the brain, an accomplice in the killing of T cells, and the refuge of HIV strains with different susceptibilities to antiviral drugs.