Perspectives

Molecular Biology: Promiscuous Chromosomal Proteins: Complexes About Sex

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Science  06 Dec 1996:
Vol. 274, Issue 5293, pp. 1633
DOI: 10.1126/science.274.5293.1633

Summary

In the phenomenon of dosage compensation, the expression of genes from the entire X chromosome is adjusted to be equivalent between the two sexes. This is necessary because one sex usually has two X chromosomes, while the other has only one. In the Perspective, Kuroda and Villeneuve explain the findings in two reports in this issue of Science from Meyer and co-workers (p. 1732 and p. 1736), in which subunits of a protein complex critical for dosage compensation are shown to be also used in the process of chromosome segregation during meiosis, suggesting that both occur by the regulated condensation of chromosomes.