Perspectives

Molecular Biology: Promiscuous Chromosomal Proteins: Complexes About Sex

+ See all authors and affiliations

Science  06 Dec 1996:
Vol. 274, Issue 5293, pp. 1633
DOI: 10.1126/science.274.5293.1633

Summary

In the phenomenon of dosage compensation, the expression of genes from the entire X chromosome is adjusted to be equivalent between the two sexes. This is necessary because one sex usually has two X chromosomes, while the other has only one. In the Perspective, Kuroda and Villeneuve explain the findings in two reports in this issue of Science from Meyer and co-workers (p. 1732 and p. 1736), in which subunits of a protein complex critical for dosage compensation are shown to be also used in the process of chromosome segregation during meiosis, suggesting that both occur by the regulated condensation of chromosomes.

Related Content