Research NewsAlzheimer's Research

Dissecting How Presenilins Function—and Malfunction

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Science  13 Dec 1996:
Vol. 274, Issue 5294, pp. 1838-1840
DOI: 10.1126/science.274.5294.1838


Two recently identified proteins are moving onto center stage in Alzheimer's disease research: the presenilins, which are mutated in about half of all inherited cases. A recent crop of results implies that these proteins play a role in the cell's internal protein-handling systems. If so, faulty presenilins could contribute to the abnormal buildup of other proteins seen in the brains of Alzheimer's patients.