Perspectives

Crossing the Hydrophobic Barrier--Insertion of Membrane Proteins

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Science  13 Dec 1996:
Vol. 274, Issue 5294, pp. 1850-1851
DOI: 10.1126/science.274.5294.1850

Summary

In this issue of Science, Song et al. (p. 1859) provide the first high-resolution x-ray view of a transmembrane protein that spontaneously inserts into the lipid bilayer. In his Perspective, Engelman discusses what these results mean for our understanding of protein insertion into membranes.