Kinase meets potassium channel

Science  20 Dec 1996:
Vol. 274, Issue 5295, pp. 1983
DOI: 10.1126/science.274.5295.1983f

Potassium channel activity affects processes, such as muscle contraction and neuronal integration, and electrophysiological and biochemical studies suggest that their activity can be modulated by serine-threonine kinases. Holmes et al. (p. 2089) noted that the human Kv1.5 potassium channel contains two repeats of the Src homology 3 (SH3) domain. They show that the native and cloned forms of this channel are associated directly with Src tyrosine kinase in human myocardium. Activation of the kinase with v-Src resulted in tyrosine phosphorylation of the channel and suppression of its current.

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