Fat cell fates

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Science  20 Dec 1996:
Vol. 274, Issue 5295, pp. 1983
DOI: 10.1126/science.274.5295.1983g

Differentiation of fat cells is inhibited by cell growth factors such as epidermal or fibroblast growth factors. Hu et al. (p. 2100) show that one of the key components in the transcription control of adipogenesis, peroxisome proliferator-activated receptor g (PPARg), is phosphorylated by mitogen-activated protein (MAP) kinase in cells that were stimulated by different growth factors. Cells expressing a PPARg mutant that could not be phosphorylated were more sensitive to induction of adipogenesis by signals such as insulin.

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