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Connexins and Disease

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Science  20 Dec 1996:
Vol. 274, Issue 5295, pp. 2008
DOI: 10.1126/science.274.5295.2008a


San Francisco—Recent work by several teams, some of which reported their results at the Congress on Cell Biology and at the annual meeting of the American Society for Cell Biology here, has linked defects in connexins, the proteins that form the cell-to-cell communication channels known as gap junctions, to conditions ranging from heart malformations to infertility and cataracts. Although most of the work has been done in mice, researchers hope the findings will lead to a better understanding of similar conditions in humans.