Research News

Gene Linked to Down Syndrome Retardation

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Science  20 Dec 1996:
Vol. 274, Issue 5295, pp. 2008-2009
DOI: 10.1126/science.274.5295.2008b


San Francisco—Because individuals who have Down syndrome have extra copies of all or part of chromosome 21, researchers have had trouble linking the many problems they suffer to any particular genes. Now several teams have evidence that the mental retardation in Down syndrome is at least partly caused by extra copies of a gene encoding an enzyme known as DYRK (for dual specificity tyrosine phosphorylation-regulated kinase) that is apparently involved in brain development.