Perspective

There Are GAPS and There Are GAPS

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Science  03 Jan 1997:
Vol. 275, Issue 5296, pp. 42-43
DOI: 10.1126/science.275.5296.42

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Summary

Guanine nucleotide-binding proteins (G proteins) transduce a very large number of cellular regulatory signals. Several recent papers have shown that the larger heterotrimeric G proteins are regulated by a class of molecules known as the RGS proteins (regulators of G protein-signaling family) that are analogous to the GAPs (GTPase activating proteins), which regulate small monomeric G proteins. Iyengar summarizes this evidence and discusses the mechanism of action of the RGS proteins.