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Early Onset of Reproductive Function in Normal Female Mice Treated with Leptin

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Science  03 Jan 1997:
Vol. 275, Issue 5296, pp. 88-90
DOI: 10.1126/science.275.5296.88

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Abstract

Numerous studies have revealed an association between nutritional status, adiposity, and reproductive maturity. The role of leptin, a hormone secreted from adipose tissue, in the onset of reproductive function was investigated. Normal prepubertal female mice injected with leptin grew at a slower rate than controls as a result of the hormone's thinning effects, but they reproduced up to 9 days earlier than controls and showed earlier maturation of the reproductive tract. These results suggest that leptin acts as a signal triggering puberty, thus supporting the hypothesis that fat accumulation enhances maturation of the reproductive tract.

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