Regulation of Cell Cycle Synchronization by decapentaplegic During Drosophila Eye Development

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Science  10 Jan 1997:
Vol. 275, Issue 5297, pp. 203-206
DOI: 10.1126/science.275.5297.203

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In the developing Drosophila eye, differentiation is coordinated with synchronized progression through the cell cycle. Signaling mediated by the transforming growth factor-β-related gene decapentaplegic (dpp) was required for the synchronization of the cell cycle but not for cell fate specification. DPP may affect cell cycle synchronization by promoting cell cycle progression through the G2-M phases. This synchronization is critical for the precise assembly of the eye.

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