Reduced Ubiquitin-Dependent Degradation of c-Jun After Phosphorylation by MAP Kinases

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Science  17 Jan 1997:
Vol. 275, Issue 5298, pp. 400-402
DOI: 10.1126/science.275.5298.400

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The proto-oncogene-encoded transcription factor c-Jun activates genes in response to a number of inducers that act through mitogen-activated protein kinase (MAPK) signal transduction pathways. The activation of c-Jun after phosphorylation by MAPK is accompanied by a reduction in c-Jun ubiquitination and consequent stabilization of the protein. These results illustrate the relevance of regulated protein degradation in the signal-dependent control of gene expression.

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