Perspective

What Makes Us Tick?

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Science  14 Feb 1997:
Vol. 275, Issue 5302, pp. 943-944
DOI: 10.1126/science.275.5302.943

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Summary

A mutant Caenorhabditis elegans worm, defective in the gene clk-1, lives an extraordinarily long time. In this issue, Ewbank et al. (p. 980) report the sequence of clk-1 and find that it is homologous to the yeast gene CAT5/COQ7, whose product regulates the transcription of genes that control yeast metabolism. In his Perspective, Guarente describes how these findings fit into a model of aging in which life-span is determined by the accumulation of damage to the organism, perhaps at a rate proportional to metabolism, and the counteracting repair of such damage.

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