Research NewsBiochemistry

Src Structure Crystallizes 20 Years of Oncogene Research

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Science  21 Feb 1997:
Vol. 275, Issue 5303, pp. 1066
DOI: 10.1126/science.275.5303.1066

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Summary

The first known cancer-causing gene is a Jekyll-and-Hyde gene called src, which is benign in normal cells but can turn dangerous when altered by a virus or by mutations. For 20 years, researchers have sought the controls for the Src protein's on-off switch. Two papers in last week's issue of Nature now reveal the crystal structure of the inactive forms of Src and a related protein, showing how this potentially dangerous molecule is restrained in normal cells.