Research NewsCancer Genetics

New Tumor Suppressor Found--Twice

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Science  28 Mar 1997:
Vol. 275, Issue 5308, pp. 1876-1878
DOI: 10.1126/science.275.5308.1876

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Two teams, one of which reports its results on (page 1943) and the other in the April issue of Nature Genetics, have ended in a near dead heat in their race to find what appears to be a particularly important tumor suppressor. The gene, located on chromosome 10, may be involved in several kinds of cancers, including gliomas, a deadly brain cancer, and prostate, breast, and kidney cancer. It encodes a protein, the amino acid sequence of which indicates that it is a tyrosine phosphatase, an enzyme that removes phosphate groups from the amino acid tyrosine. Cancer researchers had long suspected that such phosphatases might be tumor suppressors because they directly counteract the actions of another set of enzymes that play a key role in cell's growth-stimulating pathways. This is the first direct proof of that suspicion.