Research NewsBiophysics

DNA on the Big Screen

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Science  28 Mar 1997:
Vol. 275, Issue 5308, pp. 1882
DOI: 10.1126/science.275.5308.1882

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An atomic force microscope has made the first movie of an enzyme at work on a DNA molecule. By tapping an ultrafine probe across the sample, the microscope followed an RNA polymerase molecule as it ratcheted down the DNA strand, linking nucleotide bases to create an RNA template for a protein.