A Gut Reaction--Lymphoepithelial Communication in the Intestine

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Science  28 Mar 1997:
Vol. 275, Issue 5308, pp. 1897
DOI: 10.1126/science.275.5308.1897

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The vast epithelial lining of the gut has its own branch of the immune system to protect the body from invasion. In his Perspective, Shanahan describes the components of this system—the intestinal epithelial cells and intraepithelial lymphocytes—and a new local paracrine network among them, mediated by thyrotropin-releasing hormone and thyroid-stimulating hormone and reported in this issue on p. 1937 (Wang et al.)