UPDATE: PH Domains--A Universal Membrane Adapter

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Science  28 Mar 1997:
Vol. 275, Issue 5308, pp. 1899
DOI: 10.1126/science.275.5308.1899

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The enzyme PI 3-kinase seems to mediate extraordinarily diverse cellular responses to growth factors. In his Update Perspective, Hemmings offers an explanation by outlining the evidence for a common target of the phospholipid signaling molecules generated by PI 3-kinase—the pleckstrin homology (PH) domains located on at least 100 cellular proteins, which could mediate the diverse responses of cells. On p. 1927 of this issue, Klarlund et al. report the isolation of one of these PH domain-containing proteins, GRP1.