The Cis-Trans Paradox of Integrase

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Science  04 Apr 1997:
Vol. 276, Issue 5309, pp. 49-51
DOI: 10.1126/science.276.5309.49

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During recombination, strands of DNA break and are rejoined, producing the reshuffling of genetic information that underlies genetic diversity. Jayaram discusses the chemical mechanism underlying this process, including the controversial cis-trans paradox, as revealed by the x-ray crystallographic structure of the recombinase lambda integrase, reported in this issue by Kwon et al. (p. 126).