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Differential Regulation of HIV-1 Fusion Cofactor Expression by CD28 Costimulation of CD4+ T Cells

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Science  11 Apr 1997:
Vol. 276, Issue 5310, pp. 273-276
DOI: 10.1126/science.276.5310.273

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Abstract

Activation of CD4+ T lymphocytes from human immunodeficiency virus–type 1 (HIV-1)–infected donors with immobilized antibodies to CD3 and CD28 induces a virus-resistant state. This effect is specific for macrophage-tropic HIV-1. Transcripts encoding CXCR4/Fusin, the fusion cofactor used by T cell line–tropic isolates, were abundant in CD3/CD28-stimulated cells, but transcripts encoding CCR5, the fusion cofactor used by macrophage-tropic viruses, were not detectable. Thus, CD3/CD28 costimulation induces an HIV-1–resistant phenotype similar to that seen in some highly exposed and HIV-uninfected individuals.

  • * To whom correspondence should be addressed. E-mail: rin0cxj{at}bumed30.med.navy.mil

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