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The Roles of γ1 Heavy Chain Membrane Expression and Cytoplasmic Tail in IgG1 Responses

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Science  18 Apr 1997:
Vol. 276, Issue 5311, pp. 412-415
DOI: 10.1126/science.276.5311.412

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Abstract

In antibody responses, B cells switch from the expression of immunoglobulin (Ig) μ and δ heavy (H) chains to that of other Ig classes (α, γ, or ɛ), each with a distinct effector function. Membrane-bound forms of α, γ, and ɛ, but not μ and δ, have highly conserved cytoplasmic tails. Mutant mice unable to express membrane γ1 H chains or producing tailless γ1 H chains failed to generate efficient IgG1 responses and IgG1 memory. H chain membrane expression after class switching is thus required for these functions, and class switching equips the B cell antigen receptor with a regulatory cytoplasmic tail that naı̈ve B cells lack.

  • * To whom correspondence should be addressed.

  • Present address: Department of Biochemistry, Hyogo College of Medicine, Hyogo 663, Japan. E-mail: tkaisho{at}home.hyo-med.ac.jp

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