Research NewsNeuroscience

A Mitochondrial Alzheimer's Gene?

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Science  02 May 1997:
Vol. 276, Issue 5313, pp. 682
DOI: 10.1126/science.276.5313.682a

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Researchers have know for years that enzyme metabolism is low in the brains of patients with Alzheimer's disease. Now, they have evidence for a possible genetic explanation: Most of the patients have inherited a mutant--and apparently defective--form of cytochrome oxidase, a mitochondrial enzyme that is a key part of the cell's energy-producing machinery.