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Rescue of a Drosophila NF1 Mutant Phenotype by Protein Kinase A

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Science  02 May 1997:
Vol. 276, Issue 5313, pp. 791-794
DOI: 10.1126/science.276.5313.791

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Abstract

The neurofibromatosis type 1 (NF1) tumor suppressor protein is thought to restrict cell proliferation by functioning as a Ras-specific guanosine triphosphatase–activating protein. However,Drosophila homozygous for null mutations of anNF1 homolog showed no obvious signs of perturbed Ras1-mediated signaling. Loss of NF1 resulted in a reduction in size of larvae, pupae, and adults. This size defect was not modified by manipulating Ras1 signaling but was restored by expression of activated adenosine 3′,5′-monophosphate–dependent protein kinase (PKA). Thus, NF1 and PKA appear to interact in a pathway that controls the overall growth of Drosophila.

  • * Present address: Division of Pathology, The Hospital for Sick Children, 555 University Avenue, Toronto M5G 1X8, Canada.

  • To whom correspondence should be addressed. E-mail: abernards{at}helix.mgh.harvard.edu

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