Research NewsBiorhythmicity

New Clues Found to Circadian Clocks--Including Mammals'

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Science  16 May 1997:
Vol. 276, Issue 5315, pp. 1030
DOI: 10.1126/science.276.5315.1030

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Until recently, researchers wanting to understand the circadian clocks that govern an organism's daily rhythms had only three clock components to go on: two proteins from fruit flies and one from a bread mold. But with the cloning of a gene previously shown to be needed for normal circadian rhythms in the mouse, they've now gotten their first look at a mammalian clock component. That work, published in this week's issue of Cell (pp. 641 and 655), combined with the discovery of two additional bread-mold clock proteins (Science, 2 May, p. 763), suggests that the mammalian clock resembles those of simpler organisms. (Also see the Perspective on p. 1093.)