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Gene Expression Profiles in Normal and Cancer Cells

Science  23 May 1997:
Vol. 276, Issue 5316, pp. 1268-1272
DOI: 10.1126/science.276.5316.1268

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Abstract

As a step toward understanding the complex differences between normal and cancer cells in humans, gene expression patterns were examined in gastrointestinal tumors. More than 300,000 transcripts derived from at least 45,000 different genes were analyzed. Although extensive similarity was noted between the expression profiles, more than 500 transcripts that were expressed at significantly different levels in normal and neoplastic cells were identified. These data provide insight into the extent of expression differences underlying malignancy and reveal genes that may prove useful as diagnostic or prognostic markers.

  • * These authors contributed equally to this work.

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