Research NewsCell Biology

How the Nucleus Gets It Together

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Science  06 Jun 1997:
Vol. 276, Issue 5318, pp. 1495-1497
DOI: 10.1126/science.276.5318.1495

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At one time, cell biologists thought that the various reactions needed to make and then finish a messenger RNA--all of which are necessary if protein synthesis is to take place--could occur anywhere in the nucleus. But recent cytological and biochemical studies are revealing that the reactions are highly coordinated in space and time. Indeed, the synthetic and finishing reactions may be coupled with the aid of the synthesizing enzyme itself.