Research NewsImmunology

New Lead to Safer Marrow Transplants

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Science  13 Jun 1997:
Vol. 276, Issue 5319, pp. 1646
DOI: 10.1126/science.276.5319.1646

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In at least half of bone-marrow transplant patients, the donor immune cells turn against the recipient's own tissues, triggering a deadly ailment called graft-versus-host disease. Now doctors led by hematologist Claudio Bordignon at the San Raffaele Scientific Institute in Milan, Italy, may have found a solution. On page 1719 of this issue, they report the first successful human test of a gene therapy designed to halt the attack of the donated cells on the recipients' tissues.