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Essential Role of Growth Hormone in Ischemia-Induced Retinal Neovascularization

Science  13 Jun 1997:
Vol. 276, Issue 5319, pp. 1706-1709
DOI: 10.1126/science.276.5319.1706

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Abstract

Retinal neovascularization is the major cause of untreatable blindness. The role of growth hormone (GH) in ischemia-associated retinal neovascularization was studied in transgenic mice expressing a GH antagonist gene and in normal mice given an inhibitor of GH secretion (MK678). Retinal neovascularization was inhibited in these mice in inverse proportion to serum levels of GH and a downstream effector, insulin-like growth factor–I (IGF-I). Inhibition was reversed with exogenous IGF-I administration. GH inhibition did not diminish hypoxia-stimulated retinal vascular endothelial growth factor (VEGF) or VEGF receptor expression. These data suggest that systemic inhibition of GH or IGF-I, or both, may have therapeutic potential in preventing some forms of retinopathy.

  • * To whom correspondence should be addressed. E-mail: smith_lo{at}a1.tch.harvard.edu

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