Amino Acid Alchemy Transmutes Sheets to Coils

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Science  11 Jul 1997:
Vol. 277, Issue 5323, pp. 179
DOI: 10.1126/science.277.5323.179

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A group of biochemists has succeeded in converting the three-dimensional structure of a small protein from one that resembles a sheet with four flat strips lying side by side to another that resembles a collection of four helical telephone cords bunched together. They did so by altering just half the protein's amino acids—an unexpectedly small number.