The Transcriptional Paradox: Octamer Factors and B and T Cells

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Science  11 Jul 1997:
Vol. 277, Issue 5323, pp. 193-194
DOI: 10.1126/science.277.5323.193

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In their Perspective, Graef and Crabtree describe a paradox: Transcription factors are almost never expressed as specifically as their target genes. On page 221 of this issue, Zwilling et al. point to an example of this paradox for a transcription factor called BOB, which is expressed in both T and B lymphocytes of the immune system. Graef and Crabtree discuss the mechanisms by which BOB controls very different responses in these two cell types.