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Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5

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Science  11 Jul 1997:
Vol. 277, Issue 5323, pp. 225-228
DOI: 10.1126/science.277.5323.225

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Abstract

Structural changes in the extracellular matrix are necessary for cell migration during tissue remodeling and tumor invasion. Specific cleavage of laminin-5 (Ln-5) by matrix metalloprotease–2 (MMP2) was shown to induce migration of breast epithelial cells. MMP2 cleaved the Ln-5 γ2 subunit at residue 587, exposing a putative cryptic promigratory site on Ln-5 that triggers cell motility. This altered form of Ln-5 is found in tumors and in tissues undergoing remodeling, but not in quiescent tissues. Cleavage of Ln-5 by MMP2 and the resulting activation of the Ln-5 cryptic site may provide new targets for modulation of tumor cell invasion and tissue remodeling.

  • * To whom correspondence should be addressed. E-mail: quaranta{at}scripps.edu

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