Activation of Heat Shock Transcription Factor 3 by c-Myb in the Absence of Cellular Stress

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Science  11 Jul 1997:
Vol. 277, Issue 5323, pp. 246-248
DOI: 10.1126/science.277.5323.246

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In vertebrates, the presence of multiple heat shock transcription factors (HSFs) indicates that these factors may be regulated by distinct stress signals. HSF3 was specifically activated in unstressed proliferating cells by direct binding to the c-mybproto-oncogene product (c-Myb). These factors formed a complex through their DNA binding domains that stimulated the nuclear entry and formation of the transcriptionally active trimer of HSF3. Because c-Myb participates in cellular proliferation, this regulatory pathway may provide a link between cellular proliferation and the stress response.

  • * Permanent address: Research Institute for Microbial Diseases, Osaka University, Yamada-oka, Suita, Osaka 565, Japan.

  • To whom correspondence should be addressed. E-mail: sishii{at}

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