Proinsulin C-Peptide-Biological Activity?

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Science  25 Jul 1997:
Vol. 277, Issue 5325, pp. 531-532
DOI: 10.1126/science.277.5325.531

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Patients with diabetes can lead relatively normal lives when treated with the hormone insulin, although they eventually exhibit vascular and neural complications. Now a report in this week's issue by Ido et al. (p. 563) suggests that these complications might be alleviated by the simultaneous administration of C-peptide, a protein fragment cleaved from insulin during its synthesis. In his Perspective, Steiner describes how C-peptide, previously thought to be biologically inactive, may correct the vascular and neural dysfunctions of diabetes.