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A Di-Acidic Signal Required for Selective Export from the Endoplasmic Reticulum

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Science  25 Jul 1997:
Vol. 277, Issue 5325, pp. 556-558
DOI: 10.1126/science.277.5325.556

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Abstract

Transport of membrane proteins between intracellular compartments requires specific sequences in the protein cytoplasmic domain to direct packaging into vesicle shuttles. A sequence that mediates export from the endoplasmic reticulum (ER) has proved elusive. A di-acidic signal (Asp-X-Glu, where X represents any amino acid) on the cytoplasmic tail of vesicular stomatitis virus glycoprotein (VSV-G) and other cargo molecules was required for efficient recruitment to vesicles mediating export from the ER in baby hamster kidney cells. The existence of such a signal provides evidence that export from the ER occurs through a selective mechanism.

  • * To whom correspondence should be addressed. E-Mail: webalch{at}scripps.edu

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