This Week in Science

Science  25 Jul 1997:
Vol. 277, Issue 5325, pp. 453
  1. Gaining light with polymers

    Photorefractive (PR) materials can perform two-beam coupling, in which the energy from one laser beam can be transferred to another. This process can result in an optical gain, so the material acts as an optical transistor. High gains coefficients are normally associated with inorganic PR materials, but Grunnet-Jepsen et al. (p. 549; see the Perspective by Anderson, p. 530) show that by stacking thin films of PR polymers on transparent electrodes, gain coefficients can exceed unity and be as high as five. They also constructed an optical cavity that allowed a single beam to produce spontaneous oscillations. This configuration can be used to produce “time-reversed” images, which could be run back through an optical train to eliminate any introduced distortions.

  2. Cosmic markings

    Records of the past abundance of cosmogenic nuclides can be used to infer the history of the sun and geodynamo and are necessary to use cosmogenic nuclides, such as carbon-14, for dating, as discussed in a Perspective by Bard (p. 532). Plummer et al. (p. 538) infer the production history of one cosmogenic isotope, chlorine-36, over the past 40,000 years from chlorine in rat urine preserved in pack rat middens. The middens provide a useful record of production at low latitudes and may imply that production rates decreased abruptly at the end of the Pleistocene.

  3. Supercharged plates

    The beginning of the Cambrian, about 540 million years ago, was a time when animal life seems to have exploded, perhaps associated with or following changes in the composition of Earth's atmosphere and oceans. Kirschvink et al. (p. 541) compiled paleomagnetic data from several continents and suggest that this was also an unusual time for plate tectonics. The data imply that all of the major continental plates rotated and moved rapidly during the Early and Middle Cambrian. For example, Australia evidently traversed about 90 degrees in latitude within 30 million years. The authors suggest that the motion can be explained by rapid rotation of Earth's mantle and lithosphere.

  4. Pores to order

    Mesoporous silicate materials contain networks of channels with widths on the nanometer scale. McGrath et al. (p. 552) show how to tune the channel diameters over a wide range by using the lyotropic L3 phase as the template. The L3 phase is a multiply connected bilayer that divides water into two compartments, and its pore size varies continuously with surfactant concentration. The materials formed large, optically transparent monoliths, and the surfactant does not have to be removed to access the pores. Possible applications include filters, optical materials, and nanocomposites.

  5. Tragedy of the electronic commons

    Internet users are not directly charged for the amount of time or bandwidth they consume on the net. This situation can lead to greedy behavior and excessive demand for Web resources. Cases of extreme localized congestion have been observed, so called “packet storms,” in which Internet nodes are inundated with streams of data. Huberman and Lukose (p. 535; see the news story by Seife, p. 477) report observations of congestion and model the properties of this congestion. Such modeling may help in deciding how best to allocate resources to accomplish load leveling and bandwidth management.

  6. Delayed start

    The most common motor neuron disease in people is amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. In a mouse model of the human disease, in which the mice contain a mutation in copper-zinc superoxide dismutase, Kostic et al. (p. 559) tried to prevent the loss of motor neurons by crossing the mice with animals that overexpress the proto-oncogene bcl-2. The onset of the disease was delayed in offspring, and neurodegeneration was less. These results suggest that therapeutic approaches that interfere with cell death pathways may be useful in ameliorating the symptoms associated with ALS.

  7. Insulin A,B,C's

    Human insulin is synthesized as part of a larger proinsulin molecule that consists of an A chain and a B chain linked by a connecting peptide (C-peptide). The C-peptide was thought to have little if any biological activity. Ido et al. (p. 563) show that C-peptide can prevent or attenuate vascular and neural dysfunction in diabetic rats. These actions appear to be mediated by nonchiral interactions (L and D amino acids are equipotent) and therefore do not involve receptors or binding sites. The ability of C-peptide to correct the abnormalities in diabetes suggests that the peptide may be used in the treatment of diabetic complications.

  8. Doubly controlling

    The proto-oncogene protein kinase B (PKB) participates in cellular signaling through growth factor receptors. PKB is known to be activated as a consequence of increased activity of the phosphoinositide 3-kinase (PI3K), but how it was regulated has been unclear. Stokoe et al. (p. 567) report that the product of the PI3K enzyme-phosphatidylinositol 3,4,5 trisphosphate [PtdIns(3,4,5)P3]-regulates PKB in two ways. First, it stimulates a kinase that phosphorylates and activates PKB; then it binds to PKB to make a suitable substrate for the activating kinase. This complicated regulatory mechanism presumably provides close control of PKB at the correct location within the cell.

  9. Hepatitis C clone

    Hepatitis C virus (HCV), which can cause hepatitis and cirrhosis, infects more than 1 percent of the world's population. Studies of this virus have been hampered by the need to rely on patient samples, which are heterogeneous and thus cannot be used for genetic studies. Kolykhalov et al. (p. 570) have identified a consensus sequence representing a full-length clone of the virus that is infectious and disease-causing in the chimpanzee. No additional sequences or factors were required for infectivity. The ability to infect with molecularly defined material will facilitate studies of viral variation and immune selection.

  10. Manipulating magnetoresistance

    Application of a magnetic field to certain materials causes changes in their resistance; such magnetoresistance (MR) effects can be used in magnetic sensing. Ramirez and Subramanian have manipulated the colossal MR effects (CMR) in the pyroclore compound Tl2Mn2O7 in a way that cannot be achieved in the more typical CMR materials, which are manganites with a perovskite structure. They show that Sc substitution for Tl affects the electronic conduction on Tl-O lattice while leaving the magnetism essentially unchanged, which significantly enhances the CMR effect.

  11. Export codes

    Sorting of proteins within the cell occurs through interaction of particular sequences within the transported proteins with coat proteins on transport vesicles. Nishimura and Balch identified a specific sequence within the transmembrane protein VSV-G (vesicular stomatitis virus glycoprotein) that directs it to vesicles coated with the protein COPII for export from the endoplasmic reticulum (ER). The sequence Asp-X-Glu was required for export of VSV-G and could confer export from the ER on a protein that would ordinarily not be exported.

  12. Seeing yeast mitosis

    Much of our current understanding of the cell division cycle comes from genetic analysis of the budding yeast Saccharomyces cerevisiae. However, microscopic or morphologic studies of the spindle and chromosome movement have been done in more easily visualized animal or plant cells. Straight et al. developed a system to label yeast chromosomes and spindles with green fluorescent protein, which enabled them to visualize mitosis in living yeast cells. Their results reveal an initial fast and a second slower phase of chromosome separation and spindle elongation, separation of centromeres before that of telomeres, failure of the chromosomes to align on metaphase plate, and microtubule-dependent movement of the chomosomes toward the poles.

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