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Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

Science  08 Aug 1997:
Vol. 277, Issue 5327, pp. 818-821
DOI: 10.1126/science.277.5327.818

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Abstract

TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4. The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli.

  • * These authors contributed equally to this work.

  • To whom correspondence should be addressed. E-mail: aa{at}gene.com

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