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NGF Signals Ride a Trolley to Nucleus

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Science  22 Aug 1997:
Vol. 277, Issue 5329, pp. 1037
DOI: 10.1126/science.277.5329.1037

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Summary

NGF Signals Ride a Trolley to Nucleus

Researchers have known for decades that nerve growth factor (NGF) is swallowed up and packaged in vesicles that travel up neuronal axons to the cell body. But no one knew just what role this "retrograde" transport played in bringing about NGF's neuron-nurturing effects. New work described on page 1097 now shows that the transport is apparently necessary for NGF to activate CREB, a protein that regulates genes that respond to NGF.