Accelerated Aging and Nucleolar Fragmentation in Yeast sgs1 Mutants

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Science  29 Aug 1997:
Vol. 277, Issue 5330, pp. 1313-1316
DOI: 10.1126/science.277.5330.1313

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The SGS1 gene of yeast encodes a DNA helicase with homology to the human WRN gene. Mutations in WRNresult in Werner's syndrome, a disease with symptoms resembling premature aging. Mutation of SGS1 is shown to cause premature aging in yeast mother cells on the basis of a shortened life-span and the aging-induced phenotypes of sterility and redistribution of the Sir3 silencing protein from telomeres to the nucleolus. Further, in old sgs1 cells the nucleolus is enlarged and fragmentedchanges that also occur in old wild-type cells. These findings suggest a conserved mechanism of cellular aging that may be related to nucleolar structure.

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