Research NewsCancer Genetics

First p53 Relative May Be a New Tumor Suppressor

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Science  12 Sep 1997:
Vol. 277, Issue 5332, pp. 1605-1606
DOI: 10.1126/science.277.5332.1605

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Summary

Despite being one of the most studied genes in history, the p53 tumor suppressor gene had no known relatives--until now. Researchers have identified a new gene, called p73, that not only resembles p53 structurally but may have similar functions. That, plus p73's location on a part of chromosome 1 already thought to harbor one or more tumor-suppressor genes, suggests that it, too, may play a role in inhibiting cancer development.