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Repair of Adult Rat Corticospinal Tract by Transplants of Olfactory Ensheathing Cells

Science  26 Sep 1997:
Vol. 277, Issue 5334, pp. 2000-2002
DOI: 10.1126/science.277.5334.2000

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Abstract

The upper cervical corticospinal tract was transected on one side in adult rats. A suspension of ensheathing cells cultured from adult rat olfactory bulb was injected into the lesion site. This induced unbranched, elongative growth of the cut corticospinal axons. The axons grew through the transplant and continued to regenerate into the denervated caudal host tract. Rats with complete transections and no transplanted cells did not use the forepaw on the lesioned side for directed reaching. Rats in which the transplanted cells had formed a continuous bridge across the lesion exhibited directed forepaw reaching on the lesioned side.*

  • * This paper is dedicated to Diana, Princess of Wales, who inaugurated the Norman and Sadie Lee Research Centre in 1988. She gave years of unstinting support to people in wheelchairs. Her untimely death prevented her seeing this result, with which she would have been so pleased.

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