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Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

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Science  26 Sep 1997:
Vol. 277, Issue 5334, pp. 2005-2007
DOI: 10.1126/science.277.5334.2005

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Abstract

There is growing evidence that T helper cell subsets (TH1 and TH2) can be differentially recruited to promote different types of inflammatory reactions. Murine TH1 but not TH2 cells are recruited through P- and E-selectin into inflamed tissues, where they induce delayed-type hypersensitivity reactions. The human eotaxin-receptor CCR3, originally described on eosinophils and basophils, was also found to be expressed by TH2 cells. An antibody to CCR3 was used to isolate T cells from peripheral blood that give rise to TH2-polarized cell lines and to identify TH2 cells derived from naı̈ve T cells in vitro. Eotaxin stimulated increases in intracellular calcium and chemotaxis of CCR3+ T cells. The attraction of TH2 cells by eotaxin could represent a key mechanism in allergic reactions, because it promotes the allergen-driven production of interleukin-4 and interleukin-5 necessary to activate basophils and eosinophils.

  • * To whom correspondence should be addressed. E-mail: sallusto{at}bii.ch

  • Present address: Millennium Biotherapeutics Inc., Cambridge, MA 02142, USA.

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