PerspectiveRNA SYNTHESIS

MutT Prevents Leakiness

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Science  03 Oct 1997:
Vol. 278, Issue 5335, pp. 78-79
DOI: 10.1126/science.278.5335.78

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Summary

Reading the genetic code into RNA and then protein is never 100% accurate, and cells have several proofreading and editing functions to correct for this. In his Perspective Bridges discusses the mechanisms used to cleanse the RNA and DNA precursor pools of nucleotides damaged by oxidation, including one requiring the MutT protein as reported by Taddei on p. 128 of this issue.